|
KMID : 0043319990220010025
|
|
Archives of Pharmacal Research
1999 Volume.22 No. 1 p.25 ~ p.29
|
|
|
Psammaplin A, a Natural Bromotyrosine Derivative from a Sponge, Possesses the Antibacterial Activity against Methicillin-resistant Staphylococcus aureus and the DNA Gyrase-inhibitory Activity
|
|
Kim Do-Yeob
Lee Il-Sun
Jung Jee-Hyung
Yang Sung-Il
|
|
|
Abstract
|
|
|
|
Psammaplin A, a natural bromotyrosine derivative from an associated form of two sponges (Poecillastra sp. and jaspis sp.) was found to possess the antimicrobial effect on the Gram-positive bacteria, especially on methicillin-resistant Staphylococcus aureus (MRSA). The minimal inhibitory concentration of psammaplin A against twenty one MRSAs ranged from 0.781 to 6.25 , which that of ciprofloxacin was 0.391~3.125. Psammaplin A could not bind to penicillin binding protein, but inhibited the DNA synthesis and the DNA gyrase activity with the respective 50% (DNA synthesis) and 100% (DNA gyrase) inhibitory concentration 2.83 and 100 . These results indicate that psammaplin A has a considerable antibacterial activity, although restricted to a somewhat narrow range of bacteria, probably by inhibiting DNA gyrase.
|
|
|
KEYWORD
|
|
|
psammaplin A, Antibacterial activity, Staphylococcus aureus, DNA gyrase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|